Paper 36: Levels of Synovial Fluid Cytokines Predict Midterm Patient Reported Outcomes Following Arthroscopic Partial Meniscectomy

Objectives: To identify synovial fluid biomarkers associated with midterm postoperative outcomes in patients undergoing arthroscopic partial meniscectomy (APM). Methods: Subjects were prospectively enrolled a cohort of who had aspirated from their knee on the day surgery prior to APM. Biomarker analysis was performed. Preoperative patient-reported outcome (PRO) scores including VAS pain, Lysholm and Tegner activity score collected preoperatively. At minimum 2 years follow-up collected. Using previously described values, met minimal clinically important difference (MCID) for identified groups compared using parametric non-parametric tests. preoperative scores, generalized linear models used explore relationship between improvement Score, visual analog scale (VAS) pain score, KOOS-PS. Results: Fifty included study. 34 (68%) MCID 16 (32%) did not. Mean age 51 ± 9 entire cohort, no statically significant differences (p=0.35). Both majority male (p=0.37) there BMI (0.74) or time (p=0.20). On logistic regression, increased concentration RANTES (β = -6.30, p 0.04) MMP-3 -15.16, 0.001) predictive less pain. . For higher SF levels IL-1 RA greater 12.57, while reduced -10.34, 0.007). Conclusions: This study found that at surgery, intraarticular are poorer following Additionally, IL-1RA score.